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===Current and anticipated grant support===
===Current and anticipated grant support===
Overall in the last 20 years Prof. Thiene collected about 5 million Euros in grants from the European Commission,<ref>[https://www.eacts.org/faculty/gaetano-thiene/ Gaetano Thiene - European Association for Cardio-Thoracic Surgery]</ref> the Italian Ministry of Health<ref name="Ospedale"/> and Italian Ministry of Education, Charity Foundations,<ref>[https://www.ctsnet.org/home/gthiene Gaetano Thiene - The Cardiothoracic Surgery Network]</ref><ref>[https://www.c-r-y.org.uk/professor-gaetano-thiene/ Gaetano Thiene - Cardiatic Risk in the Young]</ref> Veneto Region<ref>[https://www.aulss5.veneto.it/media/aulss5/amministrazione-trasparente/consulenti-e-collaboratori/tabella-consulenti-collaboratori/curricula/THIENE_CV.pdf Gaetano Thiene - Veneto Region]</ref> and University of Padua.<ref name="Ospedale">[https://www.aopd.veneto.it/all/CV_Europeo_Gaetano_THIENE_201711.pdf Gaetano Thiene - Azienda Ospedale - Università Padova]</ref> He carried out several experimental animal studies supported by Companies in the field of bioprosthetic valves. At present, he has no current or pending grant in this issue.
Overall in the last 20 years Prof. Thiene collected about 5 million Euros in grants from the European Commission,<ref>[https://www.eacts.org/faculty/gaetano-thiene/ Gaetano Thiene - European Association for Cardio-Thoracic Surgery]</ref> the Italian Ministry of Health<ref name="Ospedale"/> and Italian Ministry of Education, Charity Foundations,<ref>[https://www.ctsnet.org/home/gthiene Gaetano Thiene - The Cardiothoracic Surgery Network]</ref><ref>[https://www.c-r-y.org.uk/professor-gaetano-thiene/ Gaetano Thiene - Cardiatic Risk in the Young]</ref> Veneto Region<ref>[https://www.aulss5.veneto.it/media/aulss5/amministrazione-trasparente/consulenti-e-collaboratori/tabella-consulenti-collaboratori/curricula/THIENE_CV.pdf Gaetano Thiene - Veneto Region]</ref> and University of Padua.<ref name="Ospedale">[https://www.aopd.veneto.it/all/CV_Europeo_Gaetano_THIENE_201711.pdf Gaetano Thiene - Azienda Ospedale - Università Padova]</ref> He carried out several experimental animal studies supported by Companies in the field of bioprosthetic valves. At present, he has no current or pending grant in this issue.
==Research==
He coordinated, within the 5th research EC program, a project on AC which resulted in the discovery of 5 disease genes of the desmosome.
Dr. Thiene has a longstanding experience in the study of valve disease and bioprosthetic structural valve deterioration. The University of Padua started implanting glutaraldeide fixed porcine xenografts in the 1970. It soon became apparent that dystrophic calcification was the major cause of failure and that the mechanism was due to deposits of calcium phospate upon due cell membrane debris full of phospholipids.<ref name="Apr1985">{{cite journal|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888085/ |title=Ultrastructural substrates of dystrophic calcification in porcine bioprosthetic valve failure |journal=The American Journal of Pathology |date=April 1985
|pmid=3985118 |first1=M. |last1=Valente |first2=U. |last2=Bortolotti |first3=G. |last3=Thiene }}</ref>
The huge burden of devices, both porcine and pericardial, implanted in Padua as valve substitutes, allowed Prof. Thiene and his group to set up the largest pathology registry in the world (>1000 explants). Several experimental and clinical investigations were carried out on second- and third-generation valve xenografts, pretreated with anticalcific agents (detergents, alchool, detoxyfing agents) with evidence of mitigation of mineralization to improve durability up to 15-20 years.<ref>{{cite journal|url=https://academic.oup.com/ejcts/article/34/2/418/413844
|title=Octanediol treatment of glutaraldehyde fixed bovine pericardium: evidence of anticalcification efficacy in the subcutaneous rat model |journal=European Journal of Cardio-Thoracic Surgery|date=August 2008 |doi=10.1016/j.ejcts.2008.05.012 |pmid=18550382 |first1=Elena |last1=Pettenazzo |first2=Marialuisa |last2=Valente |first3=Gaetano |last3=Thiene }}</ref>
More recently, the Padua group discovered the arrhythmic mitral valve syndrome leading to the risk of sudden death in the young.<ref>{{cite journal|url=https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.115.016291
|title=Arrhythmic Mitral Valve Prolapse and Sudden Cardiac Death |journal=Circulation - AHA/ASA Journal |date=9 July 2015 |doi=10.1161/CirculationAHA.115.016291 |pmid=26160859 |first1=Cristina |last1=Basso |first2=Martina |last2=Perazzolo Marra |first3=Stefania |last3=Rizzo |first4=Manuel |last4=De Lazzari |first5=Benedetta |last5=Giorgi |first6=Alberto |last6=Cipriani |first7=Anna Chiara |last7=Frigo |first8=Ilaria |last8=Rigato |first9=Federico |last9=Migliore |first10=Kalliopi |last10=Pilichou |first11=Emanuele |last11=Bertaglia |first12=Luisa |last12=Cacciavillani |first13=Barbara |last13=Bauce |first14=Domenico |last14=Corrado |first15=Gaetano |last15=Thiene |first16=Sabino |last16=Iliceto }}</ref>
== Notable publications ==
* Gaetano Thiene, Andrea Nava, Domenico Corrado, Lino Rossi, Natale Pennelli, [https://www.nejm.org/doi/full/10.1056/NEJM198801213180301 Right Ventricular Cardiomyopathy and Sudden Death in Young People], ''The New England Journal of Medicine'', 21 January 1988
* {{cite journal|url=https://www.nejm.org/doi/full/10.1056/NEJM199808063390602 |title=Screening for Hypertrophic Cardiomyopathy in Young Athletes |journal=The New England Journal of Medicine |date=6 August 1998 |doi=10.1056/NEJM199808063390602 |pmid=9691102 |first1=Domenico |last1=Corrado |first2=Cristina |last2=Basso |first3=Maurizio |last3=Schiavon |first4=Gaetano |last4=Thiene}}</ref>
* {{cite journal|url=https://www.cell.com/ajhg/fulltext/S0002-9297(07)60414-5 |title=Mutation in Human Desmoplakin Domain Binding to Plakoglobin Causes a Dominant Form of Arrhythmogenic Right Ventricular Cardiomyopathy |journal=The American Journal of Human Genetics |date=1 November 2002 |doi=10.1086/344208 |pmid=12373648 |first1=Alessandra |last1=Rampazzo |first2=Andrea |last2=Nava|first3=Sandro |last3=Malacrida |first4=Gaetano |last4=Thiene |first5=Jeffrey A. |last5=Towbin |first6=Gian A. |last6=Danieli}}
* {{cite journal|url=https://jamanetwork.com/journals/jama/fullarticle/203513 |title=Trends in Sudden Cardiovascular Death in Young Competitive Athletes After Implementation of a Preparticipation Screening Program |journal=Jama Network |date=4 October 2006 |doi=10.1001/jama.296.13.1593 |first1=Domenico |last1=Corrado |first2=Cristina |last2=Basso |first3=Andrea |last3=Pavei |first4=Pierantoni |last4=Michieli |first5=Maurizio |last5=Schiavon|first6=Gaetano |last6=Thiene}}
* {{cite journal|url=https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.117.309711 |title=Classification, Epidemiology, and Global Burden of Cardiomyopathies |journal=Circulation Research - AHA/ASA Journal |date=15 September 2017 |doi=10.1161/CIRCRESAHA.117.309711 |pmid=28912179 |first1=William J |last1=McKenna |first2=Barry J |last2=Maron |first3=Gaetano |last3=Thiene }}
* {{cite journal|url=https://academic.oup.com/eurheartj/article/36/14/837/539898 |title=The research venture in arrhythmogenic right ventricular cardiomyopathy: a paradigm of translational medicine |journal=European Heart Journal |date=7 April 2015 |doi=10.1093/eurheartj/ehu493 |pmid=25636746 |first1=Gaetano|last1=Thiene }}
* {{cite journal|url=https://www.ahajournals.org/doi/abs/10.1161/01.CIR.60.5.1066?cookieSet=1 |title=Histology of pulmonary arterial supply in pulmonary atresia with ventricular septal defect |journal=Circulation |date=1 November 1979 |doi=10.1161/01.CIR.60.5.1066 |first1=G |last1=Thiene |first2=C |last2=Frescura |first3=R M |last3=Bini |first4=M
|last4=Valente |first5=V |last5=Gallucci }}
* {{cite journal|url=https://www.jacc.org/doi/abs/10.1016/S0735-1097(00)00566-0
|title=Clinical profile of congenital coronary artery anomalies with origin from the wrong aortic sinus leading to sudden death in young competitive athletes
|journal=Journal of the American College of Cardialogy |date=May 2000 |doi=10.1016/S0735-1097(00)00566-0 |first1=Cristina |last1=Basso |first2=Barry J. |last2=Maron |first3=Domenico |last3=Corrado |first4=Gaetano |last4=Thiene }}
* {{cite journal|url=https://academic.oup.com/ejcts/article/12/5/730/347095 |title=Surgical pathology of primary cardiac and pericardial tumors |journal=European Journal of Cardio-Thoracic Surgery |date=1 November 1997 |doi=10.1016/s1010-7940(97)00246-7 |pmid=9458144 |first1=C |last1=Basso |first2=M |last2=Valente |first3=A |last3=Poletti |first4=D |last4=Casarotto |first5=G |last5=Thiene }}
* {{cite journal|url=https://www.ajconline.org/article/0002-9149(84)90638-6/pdf
|title=Calcific degeneration as the main cause of porcine bioprosthetic valve failure
|journal=The American Journal of Cardiology |date=1 April 1984 |doi=10.1016/0002-9149(84)90638-6 |pmid=6702684 |first1=A |last1=Milano |first2=U |last2=Bortolotti |first3=E
|last3=Talenti |first4=C |last4=Valfrè |first5=E |last5=Arbustini |first6=M |last6=Valente |first7=A |last7=Mazzucco |first8=V |last8=Gallucci |first9=G |last9=Thiene}}
* {{cite journal|url=https://academic.oup.com/hmg/article-abstract/3/6/959/594394?redirectedFrom=fulltext
|title=The gene for arrhythmogenic right ventricular cardiomyopathy maps to chromosome 14q23–q24 |journal=Human Molecular Genetics |date= 1 June 1994 |doi=10.1093/hmg/3.6.959
|pmid=7951245 |first1=A |last1=Rampazzo |first2=A |last2=Nava |first3=GA |last3=Danieli |first4=G |last4=Buja |first5=L |last5=Daliento |first6=G |last6=Fasoli |first7=R
|last7=Scognamiglio |first8=D |last8=Corrado |first9=G |last9=Thiene}}
* {{cite journal|url=https://www.sciencedirect.com/science/article/pii/S0735109700009979?via%3Dihub
|title=Clinical profile and long-term follow-up of 37 families with arrhythmogenic right ventricular cardiomyopathy |journal=Journal of the American College of Cardiology
|date= December 2000 |doi=10.1016/s0735-1097(00)00997-9 |pmid=11127465 |first1=A |last1=Nava |first2=B |last2=Bauce |first3=C|last3=Basso |first4=M |last4=Muriago |first5=A |last5=Rampazzo |first6=C |last6=Villanova |first7=L |last7=Daliento |first8=G |last8=Buja |first9=D |last9=Corrado |first10=GA |last10=Danieli |first11=G |last11=Thiene}}
* {{cite journal|url=https://www.ahajournals.org/doi/10.1161/01.CIR.103.2.269 |title=Ventricular Preexcitation in Children and Young Adults: Atrial Myocarditis as a Possible Trigger of Sudden Death |journal=Circulation |date=16 January 2001 |doi=10.1161/01.cir.103.2.269 |pmid=11208688 |first1=C |last1=Basso |first2=D |last2=Corrado |first3=L
|last3=Rossi |first4=G |last4=Thiene }}
* {{cite journal|url=https://journals.lww.com/molecularpathology/Abstract/2002/12000/Molecular_Diagnosis_of_Myocarditis_and_Dilated.4.aspx
|title=Molecular diagnosis of myocarditis and dilated cardiomyopathy in children: clinicopathologic features and prognostic implications |journal=Diagnostic Molecular Pathology
|date=11 December 2002 |doi=10.1097/00019606-200212000-00004 |pmid=12459637 |first1=F |last1=Calabrese |first2=E |last2=Rigo |first3=O |last3=Milanesi |first4=GM |last4=Boffa
|first5=A |last5=Angelini |first6=M |last6=Valente |first7=G |last7=Thiene}}
* {{cite journal|url=https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)67847-6/fulltext |title=Essay: Sudden death in young athletes |journal=THE LANCET
|date=1 December 2005 |doi=10.1016/S0140-6736(05)67847-6 |pmid=16360752 |first1=D |last1=Corrado |first2=C |last2=Basso |first3=G |last3=Thiene }}
* {{cite journal|url=https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.105.616490 |title=Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: Clinical Impact of Molecular Genetic Studies |journal=Circulation |date=4 April 2006 |doi=10.1161/CIRCULATIONAHA.105.616490 |pmid=16585401 |first1=D |last1=Corrado |first2=G |last2=Thiene}}
* {{cite journal|url=https://ojrd.biomedcentral.com/articles/10.1186/1750-1172-2-45 |title=Arrhythmogenic right ventricular cardiomyopathy/dysplasia |journal=Orphanet Journal of Rare Diseases |date=14 November 2007 |doi=10.1186/1750-1172-2-45 |pmid=18001465 |first1=G |last1=Thiene |first2=D |last2=Corrado |first3=C |last3=Basso }}
* {{cite journal|url=https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)60256-7/fulltext |title=Arrhythmogenic right ventricular cardiomyopathy
|journal=THE LANCET |date=11 April 2009 |doi=10.1016/S0140-6736(09)60256-7 |pmid=19362677 |first1=C |last1=Basso |first2=D |last2=Corrado |first3=FI |last3=Marcus |first4=A
|last4=Nava |first5=G |last5=Thine}}
* {{cite journal|url=https://www.sciencedirect.com/science/article/abs/pii/S1054880710000359?via%3Dihub |title=Anatomical and pathophysiological classification of congenital heart disease |journal=Cardiovascular Pathology |date=25 February 2010 |doi=10.1016/j.carpath.2010.02.006 |pmid=20466566 |first1=G |last1=Thiene |first2=C |last2=Frescura }}
* {{cite journal|url=https://www.nature.com/articles/nrcardio.2011.173 |title=Pathophysiology of arrhythmogenic cardiomyopathy |journal=Nature Reviews Cardiology
|date=29 November 2011 |doi=10.1038/nrcardio.2011.173 |pmid=22124316 |first1=C |last1=Basso |first2=B |last2=Bauce |first3=D |last3=Corrado |first4=G |last4=Thiene}}


== References ==
== References ==
<references/>
<references/>

Revision as of 11:49, 5 January 2023

Gaetano Thiene (born July 1, 1947) is an Italian Emeritus Professor of Cardiovascular Pathology at the University of Padua[1] where he graduated in 1972. He is in the list of the Top Italian Scientists.[2][3] He achieved post-graduate Diploma both in Cardiology and Pathology, which allowed him to better understand the physiopathology of morbid entities, as Consultant at the University hospital.[4]

Gaetano Thiene
Gaetano Thiene in October 2022
Born July 1st, 1947
Longare, Vicenza, Italy
Nationality Italian
Education University of Padua
Fields Cardiovascular Pathology
Cardiology
Cardiac Surgery
Genetic
Sudden Death
Cardiomyopathies
Institutions Emeritus Professor
Cardiovascular Pathology
University of Padua
Italy
Notes
Top Italian Scientist in Biomedical Sciences[2][3]

Dr. Thiene set up an interdisciplinary research team, from basic sciences to clinical wards ("from bench to bed"), with Cardiovascular Pathology playing the leading role, thus promoting translational medicine.[5] He implemented a Ph.D. course, entitled "Translational Medicine G.B. Morgagni".

Another significant step forward in applied pathology was the origin of Surgical Cardiovascular Pathology,[6] first in Europe, namely the histopathological examination of cardiovascular specimens removed at surgery for a precise nosological identification of the underlying disease. The role blew up after the first cardiac transplantation performed in Padua and first in Italy, with the cardiac rejection monitoring with endomyocardial biopsy.[7]

Last but not least, congenital heart disease had been the first research interest of Dr. Thiene, after the advent of angiography and echocardiography as diagnostic tools and of extracorporeal circulation for open heart surgery. A registry of specimens, with heart malformations, was set up since the '70s for teaching and research purposes. It now consists of 2.000 specimens, preserved in single jars, with all the date and pictures recorded in electronic files. Nowadays it is probably the best existing worldwide.[8][9]

Education and career

Curriculum studiorum

  • 1966 Scientific Lyceum Diploma, Paolo Lioy, Vicenza
  • 1972 Graduation in Medicine cum laude, University of Padua, Italy
  • 1975 Post-Graduate Specialization in Cardiology, cum laude
  • 1978 Post-Graduate Specialization in Pathology, cum laude [10]

Positions and Honors

  • 1990- Professor of Pathology
  • 1991 Ordinary Fellow, Olympic Academy, Vicenza, Italy
  • 1995-1998 Member, Administrative Council, University of Padua, Italy
  • 1998-2006 Director, Institute of Pathological Anatomy, University of Padua, Italy
  • 2002 Honorary Fellow, Royal College of Physicians, London-UK
  • 2003 Foreign Fellow, Serbian Academy of Sciences, Beograd (SERBIA)
  • 2007-2010 Vice-Director, Department of Medico-Diagnostic Sciences and Special Therapies, University of Padua, Italy
  • 2008 Active Fellow, Galileian Academy, Padua, Italy
  • 2016- current President, Olympic Academy, Vicenza, Italy[11]

Academic and Professional career

  • 1972-76 Assistant Professor, Pathology, University of Padua
  • 1976-80 Chief Assistant Professor, Pathology, University of Padua
  • 1980-90 Associate Professor, Pathology, University of Padua
  • 1990-2017 Full Professor, Pathology, University of Padua
  • 1994-2017 Director, Ph.D. School, Cardiovascular Sciences
  • 1995-2007 Director, Institute of Pathology, University of Padua
  • 2000-2017 Director, Cardiovascular Pathology Registry, Veneto Region
  • 2007-2010 Vice-Dean, Department of Medico-Diagnostic Sciences and Special Therapy, University of Padua[11]

Current and anticipated grant support

Overall in the last 20 years Prof. Thiene collected about 5 million Euros in grants from the European Commission,[12] the Italian Ministry of Health[4] and Italian Ministry of Education, Charity Foundations,[13][14] Veneto Region[15] and University of Padua.[4] He carried out several experimental animal studies supported by Companies in the field of bioprosthetic valves. At present, he has no current or pending grant in this issue.

Research

He coordinated, within the 5th research EC program, a project on AC which resulted in the discovery of 5 disease genes of the desmosome.

Dr. Thiene has a longstanding experience in the study of valve disease and bioprosthetic structural valve deterioration. The University of Padua started implanting glutaraldeide fixed porcine xenografts in the 1970. It soon became apparent that dystrophic calcification was the major cause of failure and that the mechanism was due to deposits of calcium phospate upon due cell membrane debris full of phospholipids.[7]

The huge burden of devices, both porcine and pericardial, implanted in Padua as valve substitutes, allowed Prof. Thiene and his group to set up the largest pathology registry in the world (>1000 explants). Several experimental and clinical investigations were carried out on second- and third-generation valve xenografts, pretreated with anticalcific agents (detergents, alchool, detoxyfing agents) with evidence of mitigation of mineralization to improve durability up to 15-20 years.[16]

More recently, the Padua group discovered the arrhythmic mitral valve syndrome leading to the risk of sudden death in the young.[17]

Notable publications

References

  1. ↑ Gaetano Thiene - Emeritus Professor - University of Padua
  2. ↑ 2.0 2.1 Gaetano Thiene - Top Italian Scientist in Biomedical Sciences
  3. ↑ 3.0 3.1 Top Italian Scientists in Biomedical Sciences
  4. ↑ 4.0 4.1 4.2 Gaetano Thiene - Azienda Ospedale - Università Padova
  5. ↑ Gaetano Thiene, The research venture in arrhythmogenic right ventricular cardiomyopathy: a paradigm of translational medicine, European Heart Journal, 7 April 2015
  6. ↑ C. Basso, M. Valente, A. Poletti, D. Casarotto, G. Thiene, Surgical pathology of primary cardiac and pericardial tumors, European Journal of Cardio-Thoracic Surgery, 1 November 1997
  7. ↑ 7.0 7.1 Template:Cite journal
  8. ↑ G. Thiene, C. Frescura, R. M. Bini, M. Valente, V. Gallucci, Histology of pulmonary arterial supply in pulmonary atresia with ventricular septal defect, Circulation, 1 November 1979
  9. ↑ Cristina Basso, Barry J. Maron, Domenico Corrado, Gaetano Thiene, Clinical profile of congenital coronary artery anomalies with origin from the wrong aortic sinus leading to sudden death in young competitive athletes, Journal of the American College of Cardialogy, May 2000
  10. ↑ Gaetano Thiene - University of Padua
  11. ↑ 11.0 11.1 Cite error: Invalid <ref> tag; no text was provided for refs named unipd
  12. ↑ Gaetano Thiene - European Association for Cardio-Thoracic Surgery
  13. ↑ Gaetano Thiene - The Cardiothoracic Surgery Network
  14. ↑ Gaetano Thiene - Cardiatic Risk in the Young
  15. ↑ Gaetano Thiene - Veneto Region
  16. ↑ Template:Cite journal
  17. ↑ Template:Cite journal
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