Arduino A Mangoni
Arduino A Mangoni is Strategic Professor of Clinical Pharmacology at Flinders University, Senior Consultant in Clinical Pharmacology and General Medicine and Head of the Department of Clinical Pharmacology at Flinders Medical Centre, Southern Adelaide Local Health Network, Adelaide, Australia[1][2]. His academic career has focused on investigating the effects of pharmacological and non-pharmacological interventions on the cardiovascular system, the identification of new age-related disease biomarkers and drugs targeting arginine metabolic pathways, and the safety and quality use of drugs in older patients. His clinical career has been dedicated to the management of patients with hypertension and cardiovascular risk and the implementation of deprescribing and medication management strategies in older patients. Professor Mangoni was awarded a Carrick citation for his outstanding contributions to student learning "For promotion of safe and effective medication management through an innovative e-learning pharmacology course for Nurse Practitioners in urban, rural and remote areas of Australia"[3]. Since 2011, he was awarded 6 Visiting Professorships by the University of Sassari to undertake teaching and research activities in the area of biomarker discovery in age-associated disease states[4][5]. In 2012, he was awarded the Fellowship of the British Pharmacological Society for his outstanding contributions and peer recognition in the field of pharmacology[6]. In 2019, he was awarded a Honorary Professorship in Clinical Pharmacology at the Technische Universität Dresden (Germany)[7], and in 2020 the International Society of Hypertension Fellowship for his outstanding contributions in hypertension research and patient care[8]. He is co-Editor and author of the book "Prescribing for Elderly Patients"[9].
 | |
| Born | |
| 31 July 1967 Milan, Italy | |
| Nationality | |
| Italian | |
| Education | |
| University of Milan, Italy | |
| King’s College, University of London (UK) | |
| Fields | |
| Vascular pathophysiology, Hypertension, Biomarker and drug discovery, Pharmacoepidemiology and drug safety | |
| Institutions | |
| Ospedale Maggiore and San Gerardo, University of Milan, (1992-1996) | |
| Massachusetts General Hospital, Harvard Medical School, (1996-1998) | |
| King’s College, University of London, (1998-2003) | |
| Flinders University, (2003-2009) | |
| University of Aberdeen, (2010-2012) | |
| Flinders University, (2013-pres). | |
| Notes | |
| Top Italian Scientist in Clinical Sciences | |
Education and career
Mangoni graduated in Medicine at the University of Milan in 1991. He then completed specialist training in Cardiology, Clinical Pharmacology & Therapeutics, and Internal Medicine in Italy, USA, and the UK. After being awarded a PhD in Pharmacology at King’s College, University of London, in 2003, he was appointed Senior Lecturer (2003-2007) and promoted to Associate Professor (2007-2009) in Clinical Pharmacology at Flinders University, Adelaide, Australia, before taking up the Chair in Medicine of Old Age at the University of Aberdeen (2010-2012). Since 2013, he is Strategic Professor of Clinical Pharmacology at Flinders University. In 2015-2016, he was Associate Dean and Head, Flinders Medical Science and Technology. He is elected Fellow of the Royal College of Physicians of London[10], Royal College of Physicians and Surgeons of Glasgow[11], Royal College of Physicians of Edinburgh[12], and Royal Australasian College of Physicians[13].
Research
Vasoreactivity, arterial function, and hypertension
Mangoni’s early research career focused on investigating the effects of pharmacological and non-pharmacological interventions on vasoreactivity and arterial function. He identified the critical role of heart rate and sympathetic activity in modulating arterial distensibility in animal studies[14][15]. He then demonstrated that folic acid supplementation significantly enhances endothelial-dependent vasodilatation and reduces blood pressure in high cardiovascular risk patient groups, independently of homocysteine lowering[16][17]. More recently, he participated in landmark studies defining ambulatory blood pressure targets for the diagnosis and the treatment of hypertension and the dissemination of relevant professional recommendations[18][19].
Pharmacoepidemiology and drug safety
Mangoni has investigated the cardiovascular safety of non-steroidal anti-inflammatory drugs[20], and the adverse effects of anticholinergic drugs in Australian and European cohorts[21][22][23]. More recently, he has contributed to the validation and adaptation of scoring tools predicting adverse outcomes in older patients using machine learning techniques[24], and the investigation of temporal trends in medication use in Australia[25].
Biomarker and drug discovery
Mangoni has identified, as part of an international research consortium, the biological and clinical significance of biomarkers within the arginine metabolic pathways in Australian and European patient cohorts [26][27][28][29][30]. Furthermore, he has discovered the critical role of small molecule arginine analogue inhibitors of the enzyme dimethylarginine dimethylaminohydrolase-1 in suppressing neovascularization in experimental cancer models[31][32][33].
Professional contributions
Mangoni is Editor-in-Chief of "Therapeutic Advances in Drug Safety"[34], "Current Reviews in Clinical and Experimental Pharmacology"[35], and "Clinical Medicine Insights: Cardiology"[36]. As Executive Member of the National Blood Pressure and Vascular Disease Committee of the National Heart Foundation and the Working Group of the High Blood Pressure and Research Council Australia, he revised and updated the Australian Hypertension Guidelines[37], and the Australian Guidelines on the use of Ambulatory Blood Pressure Monitoring for the management of Hypertension[19]. As Executive Member of the Guideline Development Group, Scottish Intercollegiate Guidelines Network (SIGN), he contributed to the development of the guidelines for the Management of Chronic Pain[38]. As Advisory Panel Member of the Australian College of Emergency Medicine, he contributed to the review of the efficacy and safety of thrombolysis in acute ischaemic stroke[39].
Awards and Fellowships
- Carrick citation for outstanding contributions to student learning (2007)[3].
- Fellow of the British Pharmacological Society (2012)[6].
- Six Visiting Professorships, University of Sassari, Italy[4][5].
- Honorarprofessor, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Technische Universität Dresden, Dresden, Germany (2019)[7].
- Society of Hospital Pharmacists of Australia Honour Roll: acknowledged members who have contributed their time and expertise to advance Australian pharmacy and patient care through key SHPA bodies (2019)[40].
- Fellow of the International Society of Hypertension (2020)[8].
- Fellow of the European Society of Cardiology (2004)[41].
- Fellow of the Royal Australasian College of Physicians (2005)[13].
- Fellow of the American College of Cardiology (2007)[42].
- Fellow of the Royal College of Physicians of London (2009)[10].
- Fellow of the American College of Physicians (2010)[43].
- Fellow of the American College of Clinical Pharmacology (2010)[44].
- Fellow of the Royal College of Physicians and Surgeons of Glasgow (2010)[11].
- Fellow of the Royal College of Physicians of Edinburgh (2011)[12].
References
- ↑ prof Arduino Mangoni - Flinders Univesity
- ↑ Clinical Pharmacology Services at Flinders Medical Centre
- ↑ 3.0 3.1 Arduino A Mangoni - Carrick Citations Award (2007)
- ↑ 4.0 4.1 AOUSassari - Un farmaco per prevenire i danni vascolari
- ↑ 5.0 5.1 UNIVERSITA' DEGLI STUDI DI SASSARI - Visiting Professors
- ↑ 6.0 6.1 BRITISH PHARMACOLOGICAL SOCIETY - Fellows' Directory
- ↑ 7.0 7.1 Arduino A Mangoni - Honorary Professorship in Clinical Pharmacology (2019)
- ↑ 8.0 8.1 International Society Hypertension - Fellows' Directory
- ↑ Wiley Online Library - Prescribing for Elderly Patients
- ↑ 10.0 10.1 Arduino A Mangoni - Fellow of the Royal College of Physicians of London (2003)
- ↑ 11.0 11.1 Arduino A Mangoni - Fellow of the Royal College of Physicians and Surgeons of Glasgow (2010)
- ↑ 12.0 12.1 Arduino A Mangoni - Fellow of the Royal College of Physicians of Edinburgh
- ↑ 13.0 13.1 Arduino A Mangoni - Fellow of the Royal Australasian College of Physicians (2005)
- ↑ Arduino A. Mangoni, Luca Mircoli, Cristina Giannattasio, Alberto Ferrari, Giuseppe Mancia, Heart rate-dependence of arterial distensibility in vivo, Journal of Hypertension, July 1996
- ↑ Arduino A. Mangoni, Luca Mircoli, Cristina Giannattasio, Giuseppe Mancia, Alberto U. Ferrari, Effect of Sympathectomy on Mechanical Properties of Common Carotid and Femoral Arteries, Hypertension, 1 Nov 1997
- ↑ A. A. Mangoni, R. A. Sherwood, C. G. Swift, H. D. Jackson, Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial, Journal of Internal Medicine, 11 December 2002
- ↑ Arduino A Mangoni, Stephen H D Jackson, Homocysteine and cardiovascular disease: current evidence and future prospects, The American Journal of Medicine, 1 May 2002
- ↑ Geoffrey A Head, Anastasia S Mihailidou, Karen A Duggan, Lawrence J Beilin, Narelle Berry, Mark A Brown, Alex J Bune, Diane Cowley, John P Chalmers, Peter R C Hove, Jonathan Hodgson, John Ludbrook, Arduino A Mangoni, Barry P McGrath, Mark R Nelson, James E Sharman, Michael Stowasser, Definition of ambulatory blood pressure targets for diagnosis and treatment of hypertension in relation to clinic blood pressure: prospective cohort study, the bmj, 14 April 2010
- ↑ 19.0 19.1 Geoffrey A Head, Barry P McGrath, Anastasia S Mihailidou, Mark R Nelson, Markus P Schlaich, Michael Stowasser, Arduino A Mangoni, Diane Cowley, Mark A Brown, Lee-Anne Ruta, Alison Wilson, [https://journals.lww.com/jhypertension/Abstract/2012/02000/Ambulatory_blood_pressure_monitoring_in_Australia_.2.aspx Ambulatory blood pressure monitoring in Australia: 2011 consensus position statement], Journal of Hypertension, February 2012
- ↑ Arduino A Mangoni, Richard J Woodman, Paraskevi Gaganis, Andrew L Gilbert, Kathleen M Knights, Use of non-steroidal anti-inflammatory drugs and risk of incident myocardial infarction and heart failure, and all-cause mortality in the Australian veteran community, British Journal of Clinical Pharmacology, 10 May 2010
- ↑ Estelle Lowry, Richard J Woodman, Roy L Soiza, Arduino A Mangoni, Associations between the anticholinergic risk scale score and physical function: potential implications for adverse outcomes in older hospitalized patients, JAMDA, 22 April 2011
- ↑ Arduino A Mangoni, Barbara C van Munster, Richard J Woodman, Sophia E de Rooi, Measures of anticholinergic drug exposure, serum anticholinergic activity, and all-cause postdischarge mortality in older hospitalized patients with hip fractures, The American Journal of Geriatric Phychiatric, 14 January 2013
- ↑ Arduino A Mangoni, Susan Kim Paul, Hakendorf Lidia Mayner, Richard J Woodman,Heat Waves, Drugs with Anticholinergic Effects, and Outcomes in Older Hospitalized Adults, Journal of the American Geriatrics Society, 10 May 2016
- ↑ Richard John Woodman, Kimberley Bryant, Michael J Sorich, Alberto Pilotto, Arduino Aleksander Mangoni, Use of Multiprognostic Index Domain Scores, Clinical Data, and Machine Learning to Improve 12-Month Mortality Risk Prediction in Older Hospitalized Patients: Prospective Cohort Study, Journal of Medical Internet Research, 21 June 2021
- ↑ Richard J Woodman, Chris Horwood, Aline Kunnel, Paul Hakendorf, Arduino A Mangoni, Using electronic admission data to monitor temporal trends in local medication use: Experience from an Australian tertiary teaching hospital, Frontiers in Pharmacology, 14 October 2022
- ↑ Mark A McEvoy, Peter Schofield, Wayne Smith, Kingsley Agho, Arduino A Mangoni, Michael Stowasser, Roy L Soiza, Roseanne Peel, Stephen Hancock, Brian Kelly, Kerry Inder, Ciriaco Carru, Angelo Zinellu, John Attia, Serum methylarginines and incident depression in a cohort of older adults, Journal of Affective Disorders, November 2013
- ↑ Mark McEvoy, Peter Schofield, Wayne Smith, Kingsley Agho, Arduino A Mangoni, Roy L Soiza, Roseanne Peel, John Attia, Memory impairment is associated with serum methylarginines in older adults, Current Alzheimer Research, January 2014
- ↑ S Tommasi, D J Elliot, A Hulin, B C Lewis, M McEvoy, A A Mangoni, Human dimethylarginine dimethylaminohydrolase 1 inhibition by proton pump inhibitors and the cardiovascular risk marker asymmetric dimethylarginine: in vitro and in vivo significance, Scientific Reports, 6 June 2017
- ↑ S Tommasi, D J Elliot, M Da Boit, S R Gray, B C Lewis, A A Mangoni, Homoarginine and inhibition of human arginase activity: kinetic characterization and biological relevance, Scientific Reports, 27 February 2018
- ↑ Arduino A Mangoni, Roman N Rodionov, Mark McEvoy, Angelo Zinellu, Ciriaco Carru, Salvatore Sotgia, New horizons in arginine metabolism, ageing and chronic disease states, Age and Ageing, 1 November 2019
- ↑ Sara Tommasi, Chiara Zanato, Benjamin C Lewis, Pramod C Nair, Sergio Dall'Angelo, Matteo Zanda, Arduino A Mangoni, Arginine analogues incorporating carboxylate bioisosteric functions are micromolar inhibitors of human recombinant DDAH-1, Organic & Biomolecular Chemistry, 14 December 2015
- ↑ Julie-Ann Hulin, Sara Tommasi, David Elliot, Dong Gui Hu, Benjamin C Lewis, Arduino A Mangoni, MiR-193b regulates breast cancer cell migration and vasculogenic mimicry by targeting dimethylarginine dimethylaminohydrolase 1, Scientific Reports, 25 October 2017
- ↑ Julie-Ann Hulin, Sara Tommasi, David Elliot, Arduino A Mangoni, Small molecule inhibition of DDAH1 significantly attenuates triple negative breast cancer cell vasculogenic mimicry in vitro, Biomedicine & Pharmacotherapy, March 2019
- ↑ Arduino A Mangoni - Editor-in-Chef - Therapeutic Advances in Drug Safety
- ↑ Arduino A Mangoni - Editor-in-Chef - Current Reviews in Clinical and Experimental Pharmacology
- ↑ Arduino A Mangoni - Editor-in-Chef - Clinical Medicine Insights: Cardiology
- ↑ Guideline for the diagnosis and management of hypertension in adults (2016)
- ↑ SIGN 136 • Management of chronic pain - A national clinical guideline - First published December 2013 - Revised edition published August 2019
- ↑ SYSTEMATIC REVIEW OF INTRAVENOUS THROMBOLYSIS IN ACUTE ISCHAEMIC STROKE
- ↑ SHPA - Honour Roll
- ↑ Arduino A Mangoni - Fellow of the European Society of Cardiology (2004)
- ↑ Arduino A Mangoni - Fellow of the American College of Cardiology (2007)
- ↑ Arduino A Mangoni - Fellow of the American College of Physicians (2010)
- ↑ Arduino A Mangoni - Fellow of the American College of Clinical Pharmacology (2010)
