Sandra Moreno

Sandra Moreno is Associate Professor at the Department of Biology, Roma Tre University, Rome Italy; she is also Director at the Master Program “Applied Human Embryology”, Roma Tre University, Rome Italy and Group Leader of the Developmental Biology Lab, University Roma Tre and of the Developmental Neurobiology, Neurogenetics and Molecular Neurobiology Lab, IRCCS Fondazione S. Lucia.

Nationality

Italian

Education

PhD in "Cell Differentiation and Morphogenesis", with honors, University of L’Aquila, Italy (1994)

BS/MS in "Biological Sciences", with Honors, La Sapienza University, Rome, Italy (1990)

Fields

Neuroscience

Institutions

Group Leader, Laboratory of Neurodevelopmental Biology, Neurogenetics and Molecular Neurobiology, IRCCS Fondazione S. Lucia, Rome, Italy

Director, Master Program “Applied Human Embryology”, Roma Tre University, Rome Italy.

Group Leader, Laboratory of Developmental Biology, Department of Science, Roma Tre University, Rome, Italy

Associate Professor, Department of Biology, Roma Tre University, Rome Italy.

Notes

Top Italian Scientist in Neurosciences & Psychology

Present positions

• Associate Professor
  • Comparative Anatomy & Developmental Biology
  • Molecular Neurodevelopmental biology

• Director
  • Master Program in Human Applied Embryology

• Group Leader
  • Developmental Biology Lab, University Roma Tre
  • Developmental Neurobiology, Neurogenetics and Molecular Neurobiology Lab, IRCCS Fondazione S. Lucia

Education

• 1994: PhD in "Cell Differentiation and Morphogenesis", with honors, University of L’Aquila, Italy

• 1991: National Licensure "Biology", La Sapienza University, Rome, Italy

• 1990: BS/MS in "Biological Sciences", with Honors, La Sapienza University, Rome, Italy

Faculty appointments

• 2020-present: Group Leader, Laboratory of Neurodevelopmental Biology, Neurogenetics and Molecular Neurobiology, IRCCS Fondazione S. Lucia, Rome, Italy

• 2018-present: Director, Master Program “Applied Human Embryology”, Roma Tre University, Rome Italy.

• 2017-present: Full Professor Qualified, as per the National Scientific Qualification (ASN)

• 2017-present: Group Leader, Laboratory of Developmental Biology, Department of Science, Roma Tre University, Rome, Italy

• 2014-present: Associate Professor, Department of Biology, Roma Tre University, Rome Italy.

• 2001-2014: Assistant Professor, Department of Biology, Roma Tre University, Rome Italy.

Research positions

• Nov 2022: Visiting Professor, Mitchell Center for Neurodegenerative Diseases, UTMB, Galveston, TX, USA.

• Nov 2021: Visiting Professor, Mitchell Center for Neurodegenerative Diseases, UTMB, Galveston, TX, USA.

• Feb-Mar 2020: Visiting Professor, Mitchell Center for Neurodegenerative Diseases, UTMB, Galveston, TX, USA.

• Nov 2019: Visiting Professor, Mitchell Center for Neurodegenerative Diseases, UTMB, Galveston, TX, USA.

• Oct 2006: Visiting Scientist, Laboratorio de Neurobiologìa de la Audiciòn, Salamanca, Spain.

• Nov 2005: Visiting Scientist, Department of Otolaryngology, West Virginia University, Morgantown, WV, USA.

• Oct 2005: Visiting Scientist, Department of Neuroscience, Northwestern University, Chicago, IL, USA.

• Oct-Nov 2003: Visiting Scientist, Department of Otolaryngology, West Virginia University, Morgantown, WV, USA.

• May 2002: Visiting Scientist, Department of Otolaryngology, West Virginia University, Morgantown, WV, USA.

• 1997 – 2001: Research Technician, Department of Biology, Roma Tre University, Rome, Italy

• 1995 – 1997: Post-doctoral Fellow, Department of Biology, University of L’Aquila, L’Aquila, Italy.

• Jan-Dec 1992: PhD student, Department of Biobehavioral Sciences, University of Connecticut, Storrs, CT, U.S.A.

Scientific activity

Dr. Moreno’s scientific activity is documented by 84 peer-reviewed publications (total Impact Factor 270, h-Index 32, total citations 8,244, according to Scopus) and numerous presentations at international meetings. Research interests, mostly in the neuroscience field, are as follows:

• Role of peroxisomes in health and disease, including neurodevelopment and neurodegeneration. Multiple molecular and morphological approaches are utilized to study peroxisome biogenesis and metabolism, in developing, adult, aging and degenerating central nervous system (CNS), with special reference to Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS).

• Cell death vs. survival pathways in CNS development and neurodegenerative processes. The role of apoptosis, and autophagy in the nervous system is being investigated in in vivo and in vitro models of neurodegenerative diseases, including AD and ALS.

• Involvement of antioxidant response in neurodegeneration and neuroresilience. The regulatory role played by peroxisome proliferator activated receptors (PPARs) and their cofactor PGC1α in brain oxidative stress management is studied with reference to energy metabolism pathways involving peroxisomes and mitochondria, in AD and in Non-Demented with Alzheimer’s pathology individuals” (NDAN).

• Study of pathomechanisms underlying rare neurodevelopmental disorders, by induced pluripotent stem cells (iPSCs) technology. We focus on Riboflavin Transporter Deficiency (RTD) and PCHD19, which have severe neurological implications. Patient-specific iPSCs and derived motor neurons are being investigated, with special reference to cytoskeleton, mitochondria and peroxisome dysfuntion, thanks to a collaborative effort with research groups based at Bambino Gesù Hospital.

For the above goals, combined neuromorphological and molecular approaches are utilized, including development of innovative strategies for ultrastructural investigation (e.g., FIB/SEM).

Financial support

Active support

• 2022-present: Participant to the project PNRR-MAD-2022-12375639, “Involvement of neuroprotective mechanism(s) of neuroglobin on aberrant functions related to chronic neurological diseases (988.800,00 €, funded by European Community and Health Ministry, according to the “National Recovery and Resilience Plan”).

• 2021-present: 'Principal Investigator of the project A0375-2020-36668 AMETISTA “Metabolic alterations in amyotrophic lateral sclerosis: identification of new diagnostic biomarkers and potential therapeutic target”, granted by LazioInnova (149.976,75 €, funded by Regione Lazio)

• 2020-present: Principal Investigator of the project Go for IT “Development of innovative therapeutic approaches against tau protein oligomers, biomarkers of Alzheimer's disease”, granted by Fondazione CRUI (30,000 €).

• 2018-present: Participant to “Excellence Departmental Project” on Antropocene, (Task 4: “Study of the mechanisms of neurodegeneration induced by pollutants in the atmosphere”).

• 2001-present: Principal Investigator of the project "Contribution to Laboratories and Research Activity" (CLAR) granted by Roma Tre University (2,500 €/year).

Completed support

• 2017: Annual Individual Financial Support granted by MIUR on a national competitive basis (30% Associate Professors awarded) (3,000 Euros).

• 2017: Principal Investigator of the project “International Research and Teaching Program for Doctoral Schools”, granted by Roma Tre University, for financing the Research Program on “Development of the Oesophageal Musculature”, in collaboration with Prof. Boris Kablar, MD, Ph.D. (Dalhousie School of Medicine, Halifax, Canada) (5,000 Euros).

• 2012-2013: Principal Investigator of the project "Consequences of age-related genomic instability on peroxisomal metabolism: Role of oxidative stress", granted by Roma Tre University in the context of the International Research and Training Program (12,000 Euros).

• 2011: Principal Investigator of the project “International Research and Teaching Program for Doctoral Schools”, granted by Roma Tre University, for financing the invitation and the scientific collaboration of Prof. Boris Kablar, MD, Ph.D. (Dalhousie School of Medicine, Halifax, Canada).

• 2007-2010: External collaborator to the project “SOD1-linked familial amyotrophic lateral sclerosis: novel strategies to rescue mitochondrial damage in motor neurons” (P.I. Prof. Maria Teresa Carrì), granted by Telethon (N. GGP07018),

• 2005-2008: Participant in the project “Integrated Project to decipher the biological function of peroxisomes in health and disease” (P.I. Johannes Berger; AnnaMaria Cimini), granted by the European Commission (Sixth Framework Programme, Contract No. PL512018).

• 2002-2004: Participant in the project “Effect of beta-amyloid on the production of nitric oxide (NO) constitutively generated in glial and neuronal cells in vitro” (P.I. Prof. Hisanori Suzuki; Prof. Marco Colasanti), granted by Italian Ministry of Education and Research (MIUR) (Prot. 2002063972_002).

• 1996-2000: Participant in the European Biomed Concerted Action "Peroxisomal Leukodystrophy"; Contract grant number: BMH4 CT96-1621 DGXII.

Editorial positions and reviewing activity

• Academic Editor
  • Oxidative Medicine and Cellular Longevity
  • Brain Sciences
  • RIVER - Research Innovation View Embryology Reproduction

• Associate Editor
  • American Journal of Neurodegenerative Disease

• Guest Editor
  • Current Alzheimer Research Mini-Thematic Issue “Signaling Molecules As Biomarkers And Therapeutic Targets For Alzheimer's Disease: A New Perspective” (2018)

• Books Reviewer
  • McGraw-Hill (Milano), Andreuccetti et al. (2009) “Biologia dello Sviluppo”

• Reviewer
  • Over 20 international journals

• Ad Hoc Reviewer (Grants)
  • 2015: University Tor Vergata. Consolidate the Foundations 2015. Research Proposal « Mitochondria and autophagy in degenerative synapses» (Code: 2225).
  • 2015: University Tor Vergata. Consolidate the Foundations 2015. Research Proposal «Dissecting the molecular mechanisms of ER-stress» (Code: 1743).
  • 2014: Katholieke Universiteit Leuven Research Council. Research Proposal «Peroxisomal Lipid and ROS signalling in mammalian cells» (OT/14/100).
  • 2010: FRIA (Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture), for PhD programs, Universitè Catholique de Louvain, Belgium.

Academic committees and activity

• 2019-present: Member of the Permanent Didactic Committee for Biology BS and MS programs, Faculty of Sciences, Roma Tre University, Rome, Italy

• 2010-present: Member of the Committee for Orientation in Biology, Faculty of Sciences, Roma Tre University, Rome, Italy

• 2007-present: Member of the Committee of the PhD Program in Biology, Section "Biology Applied to Human Health", Faculty of Sciences, Roma Tre University, Rome, Italy

• 2011: Member of the Committee for the admittance to Biological Sciences course, Faculty of Sciences, Roma Tre University, Rome, Italy

• 1997-2001: Chief of Technical Service for the Dept. of Biology, Interdepartmental Laboratory (LIME), Faculty of Sciences, Roma Tre University, Rome, Italy

Professional memberships and activities

• Società Italiana Embriologia Riproduzione e Ricerca (SIERR) Elected Member of the Scientific Committee

• Society for Neuroscience (SFN) Regular Member

• Federation of European Neuroscience Societies (FENS) Regular Member

• Società Italiana di Neuroscienze (SINS) Regular Member

• Gruppo Embriologico Italiano (GEI) Regular Member, Member of the Scientific Committee and of the Organizer Committee for LXIII Meeting, June 2017, Rome, Italy

Search Committees

• 2021: Member of the Examining Committee for a Researcher position, Biology Department, University of Naples “Federico II”, Italy

• 2008, 2011, 2015, 2017, 2019, 2022: Member of the Examining Committee for the admittance to Roma Tre University PhD programs (Molecular, Cellular and Environmental Biology, Biology Applied to Human Health), Rome, Italy.

• 2008: Member of the Examining Committee for an Assistant Professor position, Faculty of Biotechnologies, University of L’Aquila, Italy.

• 2007: Member of the Examining Committee for the evaluation of research and teaching activity of Dr. Andrea Di Giulio as an Assistant Professor for confirmation of his tenure position.

• 2007: Member of the Examining Committee for an Assistant Professor position, Faculty of Sciences, “Tor Vergata” University, Rome, Italy

• 2004: Member of the National Committee for the PhD final examination in Cellular and Molecular Biology, Faculty of Sciences, University of L’Aquila.

• 2001: Member of the Examining Committee for an Assistant Professor position, Faculty of Sciences, University of Milan, Italy.

Teaching and mentoring activities

Teaching

• 2020-present: Co-Course Leader for the undergraduate Course in Cell Biology & Genetics, Dept. of Science, Roma Tre University, Rome, Italy.

• 2018-present: Course Leader for the graduate Course in Laboratory of Neuroscience, Dept. of Science, Roma Tre University, Rome, Italy.

• 2014-present: Course Leader for the graduate Course in Neurodevelopmental Biology, Dept. of Science, Roma Tre University, Rome, Italy.

• 2012-present: Course Leader for the undergraduate Course in Comparative Anatomy and Developmental Biology, Dept. of Science, Roma Tre University, Rome, Italy.

• 2015-2019: Course Leader for the graduate Course in Laboratory of Electron Microscopy, Dept. of Science, Roma Tre University, Rome, Italy.

• 2007-2015: Course Leader for the graduate Course in Molecular Mechanisms in Developmental Biology, Faculty of Sciences, Roma Tre University, Rome, Italy.

• 2001-2014: Collaborator for the undergraduate course in Cytology and Histology, Faculty of Sciences, Roma Tre University, Rome, Italy.

• 2006-2012: Course Leader for the undergraduate Course in Comparative Anatomy and Embriology, Faculty of Sciences, Roma Tre University, Rome, Italy.

• 2003-2007: Course Leader for the graduate Course in Developmental Biology, Faculty of Sciences, Roma Tre University, Rome, Italy.

• 2001-2006: Course Leader for the undergraduate Course in Embryology, Faculty of Sciences, Roma Tre University, Rome, Italy.

• 1997-2001: Member of the examining Committee for the undergraduate course in Developmental Biology, Faculty of Sciences, Roma Tre University, Rome, Italy.

• 1993-1997: Teaching Assistant for the undergraduate course in General Biology with elements of Genetics, Istituto Superiore di Educazione Fisica, Cassino, Italy.

Thesis Advisor for

• 23 BS Students

• 19 MS/BS Students

PhD Students supervisor

• 2022-current: Martina Terricola

• 2019-current: Chiara Marioli

• 2017-2020: Fiorella Colasuonno

• 2016-2020: Rossella Borghi

• 2016-2019: Alessia Niceforo

• 2014-2017: Pamela Rosso, Chiara Scopa

• 2013-2016: Anna Fracassi

• 2012-2015: Barbara D'Orio, Luana Barone

• 2009-2012: Franco Capozza

• 2008-2011: Sara Sepe

• 2008-2011: Francesca Fanelli

• 2007-2010: Angela Lanciotti

• 2002-2005: Valentina Imbroglini

Post-docs

• 2021-current: Maurizio Muzzi

• 2020-current:Rachel Price

• 2019-2020: Fiorella Colasuonno

• 2016-2017: Anna Fracassi

• 2015-2016: Luana Barone

Invited seminars

• “Cellule staminali pluripotenti umane: alla ricerca di base alle applicazioni biomediche”. 11 maggio 2022, Dipartimento di Bioscienze e Territorio, Università del Molise, Pesche (IS).

• “Stem cells: an overview”. Master di II livello in Biologia e Biotecnologie delle Riproduzione: Dalla Ricerca alla Clinica, 3 febbraio 2022 Università di Pavia.

• “Peroxisomes in health and disease: A role in neurodegeneration". Department of Neurology, University of Texas Medical Branch (UTMB), Galveston (TX, USA), 27 ottobre 2019.

• “Early neurodegeneration in a mouse model of Alzheimer’s disease: role of caspase 3 and involvement of peroxisomes”. Erasmus Medical Center, Rotterdam, NL, February 14, 2011.

• Presentation of the Faculty of Sciences of Roma Tre University. Liceo “Giulio Cesare”, Roma, February 2, 2011.

• “Cell death processes: from morphology to biochemical mechanisms”. Pathological Anatomy Department, San Filippo Neri Hospital, Roma, February 22, 2010.

• “Abnormal cerebral development in an Apaf1 mouse mutant”. University of L’Aquila, June 22, 2006.

• “Role of the apoptosome in CNS development: a neuromorphological study of an Apaf1 mutant mouse model”. Institute of Neuroscience, Northwestern University, Chicago, IL, USA, 13 ottobre 2005.

• “Neuronal death in a mouse model of Huntington's chorea”, Roma Tre University, March 17, 2004.

• “Five years of biological research at the LIME: transmission electron Microscopy", Roma Tre University, December 4, 2003.

• “Neurodegeneration in a transgenic mouse model of Huntington’s disease”. Dept. of Otolaryngology, West Virginia University, Morgantown, WV, USA, May 29, 2002.

• “Neurodegeneration in a mouse model of Huntington's chorea: Role of tissue transglutaminase". University of L’Aquila, October 23, 2002.

Conference panel and meeting organization

• 2022: Chairperson for the Meeting XVI Giornate di andrologia e medicina della riproduzione. October 6-7, Sabaudia (LT), Italy.

• 2021: Chairperson for the Meeting XV Giornate di andrologia e medicina della riproduzione. October 7-8, Sabaudia (LT), Italy.

• 2021: Chairperson for the workshop “To be embryologist”. July 9, Ferrara, Italy.

• 2020: Discussant for the Meeting XIV Giornate di andrologia e medicina della riproduzione. October 15-16, Sabaudia (LT), Italy.

• 2019: Discussant for the Meeting XIII Giornate di andrologia e medicina della riproduzione. October 3-4, Sabaudia (LT), Italy.

• 2018: Chairperson for the Meeting XII Giornate di andrologia e medicina della riproduzione. October 4-5, Sabaudia (LT), Italy.

• 2017: Organizer of the LXIII GEI Meeting, June 12-15, Rome, Italy

• 2008: Organizer of the PhD student Meeting “Muscolar Differentiation in normal e pathological conditions” (Speakers: Proff. M.T. Carrì, “Tor Vergata” University, Rome, Italy; B. Kablar, Dalhousie University, Halifax, Canada; F. Protasi, Chieti University, Italy). Roma Tre University, Rome, Italy.

• 1999: Coordinator of the “Course of Professional Training in Electron Microscopy”, granted by Tecnofarmaci company, LIME, Roma Tre University, Rome, Italy.

• 1998: Coordinator of the "Course of Immunohistochemical and Immunoelectron microscopic Tecniques" for the PhD program in Biology, LIME, Roma Tre University, Rome, Italy.

Publications

1. Moreno S. Stefanini S., Di Biagio P., Hassan G. (1991) Interleukin-1 producing plasma cells in chronic active liver diseases and in kidney and liver grafts. Eur. J. Cell Biol. 55: 49. IF 1993: 2.545.

2. Cerù M.P., Giorgi M., Moreno S., Cimini A.M. (1992) Developmental pattern of peroxisomal enzymes in rat neuronal and glial cells. Neurosci. Lett. 43: S24. IF 1993: 2.645.

3. Cimini A.M., Giorgi M., Sulli A., Moreno S., Cerù M.P. (1993) Catalase activity in human neuroectodermal cell lines and in rat brain astroglial cells in culture. Biol. Cell 77 (1): 18a. IF1993: 1.175.

4. Cimini A.M., Giorgi M., Sulli A., Moreno S., Cerù M.P. (1993) Characterization of peroxisomes purified from the brains of 14-day-old rats. Biol. Cell 77: 21a. IF 1993: 1.175.

5. Cimini A., Moreno S., Giorgi M., Serafini B., Cerù M.P. (1993) Purification of peroxisomal fraction from rat brain. Neurochem. Int. 23: 249-260. IF 1993: 1.518.

6. Cimini A.M., Giorgi M., Sulli A., Moreno S., Serafini B., Cerù M.P. (1993) Effects of di(2-ethylhexyl)phthalate on peroxisomes in different organs of adult lactating and suckling rats. Biol. Cell 77: 31a. IF 1993: 1.175.

7. Harris J., Moreno S., Shaw G., Mugnaini E. (1993) Unusual neurofilament composition in cerebellar unipolar brush neurons. J. Neurocytol. 22: 1039-1059. IF 1993: 2.384.

8. Cimini A.M., Sulli A., Stefanini S., Serafini B., Moreno S., Rossi L., Giorgi M., Cerù M.P. (1994) Effects of di(2-ethylhexyl)phthalate on peroxisomes of liver, kidney and brain of lactating rats and their pups. Cell. Mol. Biol. 40: 1063-1076. IF 1994: 0.914.

9. Moreno S., Cimini A., Giorgi M., Cerù M.P. (1994) Immunocytochemical localization of Cu,Zn-superoxide dismutase in rat brain. Cell Biol. Int. 18: 520. IF 1994: 1.042.

10. Stefanini S., Sartori C., Rossi L., Moreno S., Nardacci R., Pajalunga D., Cerù M.P. (1995) Effects of ciprofibrate on liver, kidney and brain peroxisomes in lactating rats and their pups. Eur. J. Cell Biol.70. IF 1995: 2.80.

11. Moreno S., Mugnaini E., Cerù M.P. (1995) Immunocytochemical localization of catalase in the central nervous system of the rat. J. Histochem. Cytochem. 43: 1253-1267. IF 1995: 3.427.

12. Stefanini S., Serafini B., Nardacci R., Farioli Vecchioli S., Moreno S., Sartori C. (1995) Morphometric analysis of liver and kidney peroxisomes in lactating rats and their pups after treatment with the peroxisomal proliferator di-(2-ethylhexyl)phthalate. Biol. Cell 85: 167-176. IF 1995: 1.073.

13. Hassan G., Moreno S., Massimi M., Di Biagio P., Stefanini S. (1997) Interleukin-1-producing plasma cells in close contact with hepatocytes in patients with chronic active hepatitis. J. Hepatol. 27: 6-17. IF 1997: 3.409.

14. Moreno S., Nardacci R., Cerù M.P.(1997) Regional and ultrastructural immunolocalization of copper-zinc superoxide dismutase in rat central nervous system. J. Histochem. Cytochem. 45: 1611-1622. IF 1997: 2.776.

15. Moreno S., Nardacci R., Cimini A., Cerù M.P. (1999) Immunocytochemical localization of D-amino acid oxidase in rat brain. J. Neurocytol. 28: 169-185. IF 1999: 1.860.

16. Iannicola C., Moreno S., Oliverio S., Nardacci R., Ciofi-Luzzatto A., Piacentini M. (2000) Early alterations in gene expression and cell morphology in a mouse model of Huntington’s disease. J. Neurochem. 75: 830-839. IF 2000: 4.906.

17. Farioli-Vecchioli S., Moreno S., Cerù M.P. (2000) Distribution of the peroxisome proliferator-activated receptors (PPARs) in rat brain. Eur J Neurosci 12: 469. IF 3.881.

18. Farioli-Vecchioli S., Moreno S., Cerù M.P. (2001) Immunocytochemical localization of acyl-CoA oxidase in the rat central nervous system. J Neurocytol. 30: 21-33. IF 2001: 1.776.

19. Moreno S., Ferraro E., Eckert S., Cecconi F. (2002) Apaf1 reduced expression levels generate a mutant phenotype in adult brain and skeleton. Cell Death Differ. 9: 340-342. IF 2002: 8.027.

20. Corvaro M, Moreno S, Wagner M, Cecconi F (2002) Apaf1 role in neural cell death and proliferation during development. Differentiation 70: 7. IF 2002: 2.183.

21. Mastroberardino P.G., Iannicola C., Nardacci R., Bernassola F., De Laurenzi V., Melino G., Moreno S., Oliverio S., Fesus L., Piacentini M. (2002) “Tissue” transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington’s disease. Cell Death Differ. 9: 873-880. IF 2002: 8.027.

22. Cona A., Cenci F., Cervelli M., Federico R., Mariottini P., Moreno S., Angelini R. (2003) Polyamine oxidase, a hydrogen peroxide-producing enzyme, is up-regulated by light and down-regulated by auxin in the outer tissues of the maize mesocotyl. Plant Physiol. 131: 803-813. IF 2003: 5.634.

23. Moreno S., Farioli-Vecchioli S., Cerù M.P. (2004) Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS. Neuroscience 123:131-145. IF 2004: 3.456.

24. Nardacci R., Falciatori I., Moreno S., Stefanini S. (2004) Immunohistochemical localization of peroxisomal enzymes during rat embryonic development. J. Histochem. Cytochem. 52: 423-36. IF 2004: 2.513.

25. Cona A.*, Moreno S.*, Cenci F., Federico R., Angelini R. (2005) Cellular re-distribution of flavin-containing polyamine oxidase in differentiating root and mesocotyl of Zea mays L. seedlings. Planta 221: 265–276. IF 2005: 3.108. *pari contributo.

26. Cristiano L., Cimini A., Moreno S., Ragnelli A.M., Cerù M.P. (2005) Peroxisome proliferator-activated receptors (PPARs) and related transcription factors in differentiating astrocyte cultures. Neuroscience 131: 577-587. IF 2005: 3.410.

27. Persichini T., Mazzone V., Polticelli F., Moreno S., Venturini G., Clementi E., Colasanti M. (2005) Mitochondrial type I nitric oxide synthase physically interacts with cytochrome c oxidase. Neurosci. Lett. 384: 254-259. IF 2005: 1.898.

28. Moreno S., Imbroglini V., Ferraro E., Bernardi C., Romagnoli A., Berrebi A.S., Cecconi F. (2006) Apoptosome impairment during development results in activation of an autophagy program in cerebral cortex. Apoptosis 11: 1595-1602. IF 2006: 4.497.

29. Galluzzo P., Caiazza F., Moreno S., Marino M. (2007) Role of ERb palmitoylation in the inhibition of human colon cancer cell proliferation. Endocr. Relat. Cancer 14: 153-167. IF 2007: 5.193.

30. Stella L., Pallottini V., Moreno S., Leoni S., De Maria F., Turella P., Federici G., Fabrini R., Dawood K. F., Lo Bello M., Pedersen J. Z., Ricci G. (2007) Electrostatic association of glutathione transferase to the nuclear membrane. Evidence of an enzyme defense barrier at the nuclear envelope. J. Biol. Chem. 282: 6372-6379. IF 2007: 5.581.

31. Ferri A., Nencini M., Cozzolino M., Carrara P., Moreno S., Carrì M.T. (2008) Inflammatory cytokines increase mitochondrial damage in motoneuronal cells expressing mutant SOD1. Neurobiol. Dis. 32: 454–460. IF 2008: 4.852.

32. Cimini A.*, Moreno S.*, D’Amelio M., Cristiano L., D’Angelo B., Falone S., Benedetti E., Carrara P., Fanelli F., Cecconi F., Amicarelli F., Cerù M.P. (2009) Early biochemical and morphological modifications in the brain of a transgenic mouse model of Alzheimer disease. A role for peroxisomes. J. Alzh. Dis. 18: 935–952. IF 2008: 3.832. *equal contribution.

33. Fazi B., Biancolella M., Mehdawy B, Corazzari M., Minella D., Blandini F, Moreno S., Nardacci R., Nisticò R., Sepe S., Novelli G., Piacentini M., Di Sano F. (2010) Characterization of gene expression induced by RTN-1C in human neuroblastoma cells and in mouse brain. Neurobiol. Dis. 40: 634-644. IF 2010: 5.121.

34. Ferri A., Fiorenzo P., Nencini M., Cozzolino M., Pesaresi M.G., Valle C., Sepe S., Moreno S., Carrì M.T. (2010) Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity. Hum. Mol. Genet. 19: 4529-4542. IF 2010: 8.058.

35. D’Amelio M., Cavallucci V., Middei S., Pacioni S., Marchetti C., Ferri A., Diamantini A., De Zio D., Carrara P., Battistini L., Moreno S., Marie H., Bacci A., Ammassari-Teule M., Cecconi F. (2011) Caspase-3 triggers dendritic spine loss at the onset of cognitive decline in a mouse model of Alzheimer's disease. Nature Neurosci. 14: 69-76. IF 2011: 15.531.

36. Tisi A., Federico R., Moreno S., Lucretti S., Moschou P.N., Roubelakis-Angelakis K.A., Angelini R., Cona A. (2011) Perturbation of polyamine catabolism can strongly affect root development and xylem differentiation. Plant Physiol. 157: 200–215. IF 2011: 6.535.

37. Trapani L., Melli L., Segatto M., Trezza V., Campolongo P., Jozwiak A., Swiezewska E., Pucillo L.P., Moreno S., Fanelli F., Linari M., Pallottini V. (2011) Effects of myosin heavy chain (MHC) plasticity induced by HMGCoA-reductase inhibition on skeletal muscle functions. FASEB J. 25: 4037-4047. IF 2011: 5.712.

38. Cacchi S., Caponetti E., Casadei M.A., Di Giulio A., Fabrizi G., Forte G., Goggiamani A., Moreno S., Paolicelli P., Petrucci F., Prastaro A., Saladino M.L. (2012) Suzuki-Miyaura cross-coupling of arenediazonium salts catalyzed by alginate/gellan-stabilized palladium nanoparticles under aerobic conditions in water. Green Chem., 14, 317-320. IF 2012: 6.828.

39. Viscomi M.T., D’Amelio M., Cavallucci V., Latini L., Bisicchia E., Nazio F., Fanelli F., Maccarrone M., Moreno S., Cecconi F., Molinari M. (2012) Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage. Autophagy 8: 222-235. IF 2012: 12.042.

40. D’Eletto M., Farrace M.G., Rossin F., Strappazzon F., Di Giacomo G.D., Cecconi F., Melino G., Sepe S., Moreno S., Fimia G.M., Falasca L., Nardacci R., Piacentini M. (2012) Type 2 transglutaminase is involved in the autophagy-dependent clearance of ubiquitinated proteins. Cell Death Differ. 19: 1228-1238. IF 2012: 8.371.

41. Trapani L., Segatto M., La Rosa P., Fanelli F., Moreno S., Marino M., Pallottini V. (2012) 3-hydroxy 3-methylglutaryl coenzyme a reductase inhibition impairs muscle regeneration. J Cell Biochem. 113: 2057-2063. IF 2012: 3.062.

42. Fanelli F., Sepe S., D'Amelio M., Bernardi C., Cristiano L., Cimini A., Cecconi F., Cerù M.P., Moreno S. (2013) Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer's disease. Mol. Neurodeg. 8:8. IF 2013: 5.286.

43. Cervelli M., Bellavia G., D'Amelio M., Cavallucci V., Moreno S., Berger J., Nardacci R., Marcoli M., Maura G., Piacentini M., Amendola R., Cecconi F., Mariottini P. (2013) A new transgenic mouse model for studying the neurotoxicity of spermine oxidase dosage during ageing and in the response to excitotoxic injury. PLoS One, Jun 19;8(6): e64810. IF 2013: 3.534.

44. Nieri D., Fioramonti M., Berardinelli F., Leone S., Cherubini R., De Nadal V., Gerardi S., Moreno S., Nardacci R., Tanzarella C., Antoccia A. (2013) Radiation response of chemically-derived mitochondrial DNA-deficient AG01522 human primary fibroblasts. Mutat. Res. 756: 86-94. IF 2013: 2.481.

45. D’Orio B., Barone L., Fracassi A., Fanelli F., Sepe S., Segatto M., Piacentini M., Nardacci R., Moreno S. (2013). Altered expression of antioxidant enzymes and autophagic proteins in transglutaminase 2 knockout mice. Molecular Neurodegeneration 8 (Suppl.1): P15. IF 2013: 5.286.

46. Angelucci E., Moreno S., D’Amelio M., Nardacci R., Cecconi F., Mariottini P., Cervelli M. (2013) A new transgenic mouse model for studying the neurotoxicity of spermine oxidase dosage in the response to excitotoxic injury. Molecular Neurodegeneration 8 (Suppl 1): P4. IF 2013: 5.286.

47. Segatto M., Rosso P., Moreno S., Pallottini V. (2013) Analysis of the protein network of cholesterol homeostasis maintenance in a mouse model of Alzheimer’s disease. Molecular Neurodegeneration, 8 (Suppl 1): P37. IF 2013: 5.286.

48. Sepe S., Nardacci R., Fanelli F., Rosso P., Bernardi C., Cecconi F., Mastroberardino P.G. , Piacentini M., Moreno S. (2014) Expression of Ambra1 in mouse brain during physiological and Alzheimer type aging. Neurobiol. Aging 35: 96-108. IF 2014: 5.013.

49. Segatto M, Manduca A, Lecis C., Rosso P., Jozwiak A., Swiezewska E., Moreno S., Trezza V., Pallottini V. (2014) Simvastatin treatment highlights a new role for the isoprenoid/cholesterol biosynthetic pathway in the modulation of emotional reactivity and cognitive performance in rats. Neuropsychopharmacology, 39: 841-854. IF 2013: 7.833.

50. Benedetti E., D’Angelo B., Cristiano L., Di Giacomo E., Fanelli F., Moreno S., Cecconi F., Fidoamore A., Antonosante A., Falcone R., Ippoliti R., Giordano A., Cimini A. (2014) Involvement of peroxisome proliferator-activated receptor β/δ (PPAR β/δ) in BDNF signalling during aging and in Alzheimer’s disease: possible role of 4-hydroxynonenal (4-HNE). Cell Cycle, 13(8): 1335-1344. IF 2014: 4.565.

51. Fidaleo M., Fanelli F., Cerù M.P., Moreno S. (2014) Neuroprotective properties of peroxisome proliferator-activated receptor alpha (PPARα) and its lipid ligands. Curr. Med. Chem., 21: 2803-2821. IF 2014: 3.853.

52. Fidaleo M., Fracassi A., Zuorro A., Lavecchia R., Moreno S., Sartori C. (2014) Cocoa protective effects against abnormal fat storage and oxidative stress induced by a high-fat diet involve PPARα-signalling activation. Food Funct. 5: 2931-2939. IF 2014: 2.791.

53. Cavallucci V., Bisicchia E., Cencioni M.T., Ferri A., Latini L., Nobili A., Biamonte F., Nazio F., Fanelli F., Moreno S., Molinari M., Viscomi M.T., D’Amelio M. (2014) Acute focal brain damage alters mitochondrial dynamics and autophagy in axotomized neurons. Cell Death Dis. 5: e1545. IF 2014: 5.014.

54. Porcellotti S., Fanelli F., Fracassi A., Sepe S., Cecconi F., Bernardi C., Cimini A., Cerù M.P., Moreno S. (2015) Oxidative stress during the progression of β-amyloid pathology in the neocortex of the Tg2576 mouse model of Alzheimer's disease. Oxid Med Cell Longev 2015: 967203, 18 pp. IF 2015: 4.492.

55. Moreno S., Cerù M.P. (2015) In search for novel strategies towards neuroprotection and neuroregeneration: is PPARα a promising therapeutic target? Neural Regen Res, 10(9):1409-1412. IF 2015: 0.968.

56. Rosso P., Moreno S., Fracassi A., Rocco M.L., Aloe L. (2015) Nerve growth factor and autophagy: effect of nasal anti-NGF-antibodies administration on Ambra1 and Beclin-1 expression in rat brain. Growth Factors 33(5-6): 401-409. doi: 10.3109/08977194.2015.1122002. IF 2015: 2.043.

57. Klionsky DJ, ..., Moreno S, ... et al. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1):1-222. IF 2016: 8.593.

58. Baguma-Nibasheka M., Fracassi A., Costain W.J., Moreno S., Kablar B. (2016) Role of skeletal muscle in motor neuron development. Histol and Histopathol, 31(7): 699-719. doi: 10.14670/HH-11-742. IF 2016: 2.025.

59. Sepe S., Milanese C., Gabriels S., Derks K.W.J., Payan-Gomez C., van IJcken W.F.J., Rijksen Y.M.A., Nigg A.L., Moreno S., Cerri S., Blandini F., Hoeijmakers J.H. J., Mastroberardino P.G. (2016) Inefficient DNA repair is an aging-related modifier of Parkinson’s disease. Cell Reports, 15: 1–10. IF 2016: 8.282.

60. Fracassi A., Colasuonno F., Taglialatela G., Moreno S. (2016) Early alterations in the expression of antioxidant enzymes and oxidative stress markers in neurogenic niches of TG2576 mouse model of Alzheimer's disease. J. Alzh. Dis. 53: S32-S33. IF 2016: 3.731.

61. Di Giacomo E., Benedetti E., Cristiano L., Antonosante A., D'Angelo M., Fidoamore A., Barone D., Moreno S., Ippoliti R., Cerù M.P., Giordano A., Cimini A. (2017) Roles of PPAR transcription factors in the energetic metabolic switch occurring during adult neurogenesis. Cell Cycle 16(1): 59–72. DOI: 10.1080/15384101.2016.1252881. IF 2016: 3.530.

62. Rosso P., De Nicolò S., Carito V., Fiore M., Iannitelli A., Moreno S., Tirassa P. (2017) Ocular NGF administration modulates BDNF signaling in prefrontal cortex of healthy and diabetic rats. CNS Neurosci Ther, Jan 3. doi: 10.1111/cns.12661. IF 2016: 3.919

63. Petrini S., Borghi R., D'Oria V., Restaldi F., Moreno S., Novelli A., Bertini E., Compagnucci C. (2017) Aged induced pluripotent stem cell (iPSCs) as a new cellular model for studying premature aging. Aging (Albany NY). 9(5): 1453–1466. doi: 10.18632/aging.101248. IF 2016: 4.867.

64. Borghi R., Petrini S., Colasuonno F., D’Oria V., Niceforo A., Bertini E., Compagnucci C., Moreno S. (2017) Nuclear and mitochondrial alterations in long-term cultures of induced pluripotent stem cells. Eur J Histochem 61 (suppl. 1): 5. IF 2016: 2.306.

65. Fracassi A., Moreno S., Taglialatela G. (2017) Oxidative stress and antioxidant response in the frontal cortex of demented and non-demented individuals with Alzheimer’s neuropathology. Eur J Histochem 61 (suppl. 1): 13-14. IF 2017: 2.306.

66. Niceforo A., Colasuonno F., Muzzi M., Borghi R., Di Giulio A., Bertini E., Moreno S., Compagnucci C. (2017) Using induced pluripotent stem cells (IPSCs) to study a rare human developmental disease associated with riboflavin deficiency. Eur J Histochem 61 (suppl. 1): 21. IF 2017: 2.306.

67. Rosso P., Carito V., Moreno S., Tirassa P. (2017) Impact of acute inflammation on neurogenesis in rat subventricular zone. Eur J Histochem 61 (suppl. 1): 25. IF 2017: 2.306.

68. Scopa C., Fracassi A., Scardigli R., Moreno S. (2017) The role of peroxisomes during adult neurogenesis in a mouse model of Alzheimer's disease. Eur J Histochem 61 (suppl. 1): 27-28. IF 2017: 2.306.

69. Colasuonno F., Borghi R, Niceforo A., Muzzi M., Bertini E., Di Giulio A., Moreno S.*, Compagnucci C.* (2017) Senescence‐associated ultrastructural features of long‐term cultures of induced pluripotent stem cells (iPSCs) Aging (Albany NY) 9(10): 2206-2222. doi: 10.18632/aging.101309. IF 2017: 4.867. *equal contribution.

70. Moreno S (2018) Signaling molecules as biomarkers and therapeutic targets for Alzheimer's Disease: A New Perspective. Curr Alzh Res 15(4): 302. DOI: 10.2174/156720501504180222162435. IF 2018: 3.289.

71. D’Orio B., Fracassi A., Cerù M.P., Moreno S. (2018). Targeting PPARα in Alzheimer’s disease. Curr Alzh Res, 15: 1-10. doi: 10.2174/1567205014666170505094549. IF 2018: 3.289.

72. Colasuonno F., Muzzi M., Borghi R., Niceforo A., Fracassi A., Compagnucci C., Di Giulio A., Moreno S. Ultrastructural analysis of cell senescence features in induced pluripotent stem cells. Eur J Histochem 61 (suppl. 4): 2. IF 2018: 2.217.

73. Salvatori I., Ferri A., Scaricamazza S., Giovannelli I., Serrano A., Rossi S., D’Ambrosi N., Cozzolino M., Di Giulio A., Moreno S., Valle C., Carrì M.T. (2018) Differential toxicity of TAR DNA-binding protein 43 isoforms depends on their submitochondrial localization in neuronal cells. J Neurochem 146(5): 585-597. doi: 10.1111/jnc.14465. IF 2018: 4.87.

74. Baguma-Nibasheka M., Fracassi A., Costain W.J., Moreno S., Kablar B. (2019) Striated-for-smooth muscle replacement in the developing mouse esophagus. Histol Histopathol. 30:18087. doi: 10.14670/HH-18-087. IF 2019: 1.777.

75. Colasuonno F, Niceforo A, Marioli C, Fracassi A, Stregapede F, Massey K, Tartaglia M, Bertini E, Compagnucci C, Moreno S. (2020) Mitochondrial and peroxisomal alterations contribute to energy dysmetabolism in riboflavin transporter deficiency. Oxidat Med Cell Longev, 2020: 6821247, 19 pp. IF 2020: 5.076.

76. Colasuonno F, Bertini E, Tartaglia M, Compagnucci C, Moreno S (2020) Mitochondrial abnormalities in induced pluripotent stem cells-derived motor neurons from patients with riboflavin transporter deficiency. Antioxidants 9, 1252. IF 2020: 5.014.

77. Marioli C, Magliocca V, Petrini S, Niceforo A, Borghi R, Petrillo S, La Rosa P, Colasuonno F, Persichini T, Piemonte F, Massey K, Tartaglia M, Moreno S, Bertini E, Compagnucci C. (2020) Antioxidant Amelioration of Riboflavin Transporter Deficiency in Motoneurons Derived from Patient-Specific Induced Pluripotent Stem Cells. Int J Mol Sci 21(19): 7402. doi: 10.3390/ijms21197402. IF 2020: 5.923.

78. Klionsky DJ, ..., Moreno S, ... et al. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. Jan 17(1): 1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. IF 2020: 9.770.

79. Niceforo A, Marioli C, Colasuonno F, Petrini S, Massey K, Tartaglia M, Bertini E, Moreno S*, Compagnucci C* (2021) Altered cytoskeletal arrangement in induced pluripotent stem cells (iPSCs) and motor neurons from patients with riboflavin transporter deficiency. Dis Model Mech., Jan 19:dmm.046391. doi: 10.1242/dmm.046391. Epub ahead of print. IF 2020: 4.028 *equal contribution.

80. Borghi R, Magliocca V, Petrini S, Conti LA, Moreno S, Bertini E, Tartaglia M, Compagnucci C (2021) Dissecting the role of PCDH19 in clustering epilepsy by exploiting patient-specific models of neurogenesis. J Clin Med 10(13): 2754. doi: 10.3390/jcm10132754. IF 2020: 3.303.

81. Fracassi A, Marcatti M, Zolochevska O, Tabor N, Woltjer R, Moreno S*, Taglialatela G* (2021) Oxidative damage and antioxidant response in frontal cortex of demented and non-demented individuals with Alzheimer’s neuropathology. J Neurosci 41(3):538-554. doi: 10.1523/JNEUROSCI.0295-20.2020. Epub 2020 Nov 25. *equal contribution. IF 2021: 6.709.

82. Murdocca M, Spitalieri P, Cappello A, Colasuonno F, Moreno S, Candi E, D'Apice MR, Novelli G, Sangiuolo F (2022) Mitochondrial dysfunction in mandibular hypoplasia, deafness and progeroid features with concomitant lipodystrophy (MDPL) patients. Aging 14(4): 1651-1664. doi:10.18632/aging.203910. IF 2021: 5.955.

83. Colasuonno F, Marioli C, Tartaglia M, Bertini E, Compagnucci C, Moreno S. (2022) New insights into the neurodegeneration mechanisms underlying Riboflavin Transporter Deficiency (RTD): involvement of energy dysmetabolism and cytoskeletal derangement. Biomedicines 10(6): 1329. doi:10.3390/biomedicines10061329. IF 2022: 4.757.

84. Fracassi A, Marcatti M, Tumurbaatar B, Woltjer R, Moreno S, Taglialatela G. (2022) Trem2-induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology. Brain Pathol Jul 11; e13108. doi: 10.1111/bpa.13108. IF 2021: 7.611.

85. Marinaccio J, Micheli E, Udroiu I, Di Nottia M, Carrozzo R, Baranzini N, Grimaldi A, Leone S, Moreno S, Muzzi M, Sgura A (2023) TERT extra-telomeric roles: antioxidant activity and mitochondrial protection. Int J Mol Sci 24(5):4450. doi: 10.3390/ijms24054450. IF 2023:6.208.

86. Montalesi E, Cracco P, Acconcia F, Fiocchetti M, Iucci G, Battocchio C, Orlandini E, Ciccone L, Nencetti S, Muzzi M, Moreno S, Venditti I, Marino M (2023) Resveratrol Analogs and Prodrugs Differently Affect the Survival of Breast Cancer Cells Impairing Estrogen/Estrogen Receptor α/Neuroglobin Pathway. Int J Mol Sci 24(3): 2148. doi:10.3390/ijms24032148. IF 2023:6.208.

87. Martella N, Pensabene D, Varone M, Colardo M, Petraroia M, Sergio W, La Rosa P, Moreno S, Segatto, M (2023) Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-ing on Epigenetic Regulation. Biomedicines 11(3): 750. doi:10.3390/biomedicines11030750. IF 2022: 4.757.