Isabella Quinti

Isabella Quinti is a Full Professor in Internal Medicine, Clinical Immunology, the School Director of Specialty in Allergy and Clinical Immunology and the Head of the Primary Immunodeficiency Unit at the Sapienza University of Rome, Italy.

Isabella Quinti

Born

1954

Nationality

Italian

Education

Sapienza University of Rome, Italy

Fields

Immunology

Institutions

Sapienza University of Rome, Italy

Notes

Top Italian Scientist in Clinical Sciences

Work experience

• 1986-2002: Assistant Professor in Clinical Immunology, University of Rome “La Sapienza”, Italy.
• 2001-up to now: Head of the Primary Immunodeficiency Unit, Sapienza, University of Rome, Italy.
• 2010-up to now: Professor PhD School, INNOVATION IN IMMUNO-MEDIATED AND HEMATOLOGICAL DISORDERS, Sapienza, University of Rome, Italy.
• 2019-up to now: Director School of Specialty in Allergy and Clinical Immunology, Sapienza University of Rome, Sapienza, University of Rome, Italy.
• 2012-2020: Associate Professor in Internal Medicine, Clinical Immunology, Sapienza, University of Rome, Italy.
• 2021-up to now: Full Professor in Internal Medicine, Clinical Immunology, Sapienza, University of Rome, Italy.

Education and training

• 1972-1978: Medicine Degree, Sapienza University of Rome, Italy.
• 1978-1982: Specialist in Allergy and Clinical Immunology, Sapienza University of Rome, Italy.
• 1983-1984: Research fellow in Paediatrics, Children Hospital, Harvard University, Boston, Ma, USA.
• 1983-1985: Ph.D. in Clinical Immunology, University of Bari, Italy.

Scientific skills and competences

• Primary Immunodeficiencies: natural history, clinical outcome, immune therapies.
• Blymphocytes defects in primary immunodeficiencies syndromes.
• Response to Immunizations.
• B-cell lymphoproliferative disorders.
• Mucosal immunity.

Relevant roles and competences

• 2001 up to now: Responsible for Italian Network on CVID (IPINET: Italian Primary Immunodeficiency Network).
• 2008-2015: Responsible for the Sapienza Research Unit of the Medium-scale focused research Collaborative Research Project, founded by the European Commission:“Pathophysiology and Natural Course of Primary Antibody Deficiency (PAD) Syndromes (EURO-PADnet). 7° PQ EU.
• 2010-2022: Responsible of the Jeffrey Modell Foundation for the Italian Primary Immune Deficiencies Centre.
• 2009-2016: Coordinator of the Project: Role of antibiotic prophylaxis in patients with primary antibody deficiencies, founded by AIFA (Italian Agency of Drugs) Agenzia Italiana del Farmaco/AIFA.
• 2020 up to now: Responsible of the project: IVIG in COVID-19 founded by AIFA (Italian Agency for drugs).
• 2021-2022: Call for prevention, GSK.

Relevant Publications (last five years)

1. Fernandez Salinas A., Piano Mortari E., Terreri S., Milito C., Zaffina S., Perno C. F., Locatelli F., Quinti I., Carsetti R. (2022). Impaired memory B-cell response to the Pfizer-BioNTech COVID-19 vaccine in patients with common variable immunodeficiency. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 149, p. 76-77, ISSN: 0091-6749, doi: 10.1016/j.jaci.2021.08.031 - Articolo in rivista.

1. Quinti I., Locatelli F., Carsetti R. (2022). The Immune Response to SARSCoV-2 Vaccination: Insights Learned From Adult Patients With Common Variable Immune Deficiency. FRONTIERS IN IMMUNOLOGY, vol. 12, ISSN: 1664-3224, doi: 10.3389/fimmu.2021.815404 - Articolo in rivista.

1. Isabella Quinti, Ivano Mezzaroma, Cinzia Milito (2021). Clinical management of patients with primary immunodeficiencies during the COVID-19 pandemic. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, p. 1-6, ISSN: 1744-666X, doi:10.1080/1744666X.2021.1873767 - Articolo in rivista.

1. Milito C., Lougaris V., Giardino G., Punziano A., Vultaggio A., Carrabba M., Cinetto F., Scarpa R., Delle Piane R. M., Baselli L., Ricci S., Rivalta B., Conti F., Marasco C., Marzollo A., Firinu D., Pulvirenti F., Lagnese G., Vivarelli E., Cancrini C. (2021). Clinical outcome, incidence, and SARS-CoV-2 infectionfatality rates in Italian patients with inborn errors of immunity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. IN PRACTICE, vol. 9, p. 2904-2906.e2, ISSN: 2213-2198, doi: 10.1016/j.jaip.2021.04.017 - Articolo in rivista.

1. Milito C., Soccodato V., Auria S., Pulvirenti F., Quinti I. (2021). COVID-19 in complex common variable immunodeficiency patients affected by lung diseases. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, vol. 21, p. 535-544, ISSN: 1473-6322, doi: 10.1097/ACI.0000000000000789 - Articolo in rivista.

6. Pulvirenti, Federica, Fernandez Salinas, Ane, Milito, Cinzia, Terreri, Sara, Piano Mortari, Eva, Quintarelli, Concetta, Di Cecca, Stefano, Lagnese, Gianluca, Punziano, Alessandra, Guercio, Marika. (2021). B Cell Response Induced by SARS-CoV-2 Infection Is Boosted by the BNT162b2 Vaccine in Primary Antibody Deficiencies. CELLS, vol. 10, p. 1-15, ISSN: 2073-4409, doi: 10.3390/cells10112915 - Articolo in rivista 7. Pulvirenti, Federica, Milito, Cinzia, Cinetto, Francesco, Salinas, Ane Fernandez, Terreri, Sara, Mortari, Eva Piano, Auria, Stefania, Soccodato, Valentina, Miriam, Lichtner, Nicastri, Emanuele. (2021). SARS-CoV-2 monoclonal antibody combination therapy in patients with COVID-19 and primary antibody deficiency. THE JOURNAL OF INFECTIOUS DISEASES, ISSN: 0022-1899, doi: 10.1093/infdis/jiab554 - Articolo in rivista 8. Salinas A. F., Mortari E. P., Terreri S., Quintarelli C., Pulvirenti F., Di Cecca S., Guercio M., Milito C., Bonanni L., Auria S., Romaggioli L., Cusano G., Albano C., Zaffina S., Perno C. F., Spadaro G., Locatelli F., Carsetti R., Quinti I. (2021). SARS-CoV-2 Vaccine Induced Atypical Immune Responses in Antibody Defects: Everybody Does their Best. JOURNAL OF CLINICAL IMMUNOLOGY, vol. 41, p. 1709-1722, ISSN: 0271-9142, doi: 10.1007/s10875-021-01133-0 - Articolo in rivista 9. Thalhammer J., Kindle G., Nieters A., Rusch S., Seppanen M. R. J., Fischer A., Grimbacher B., Edgar D., Buckland M., Mahlaoui N., Ehl S., Boztug K., Brunner J., Demel U. F., Forster-Waldl E., Gasteiger L. M., Goschl L., Kojic M., Schroll A., Seidel M. G. (2021). Initial presenting manifestations in 16,486 patients with inborn errors of immunity include infections and noninfectious manifestations. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN: 0091-6749, doi: 10.1016/j.jaci.2021.04.015 - Articolo in rivista 10. Carsetti R., Di Sabatino A., Rosado M. M., Cascioli S., Piano Mortari E., Milito C., Grimsholm O., Aranburu A., Giorda E., Tinozzi F. P., Pulvirenti F., Donato G., Morini F., Bagolan P., Corazza G. R., Quinti I. (2020). Lack of gut secretory immunoglobulin A in memory B-cell dysfunction-associated disorders: a possible gut-spleen axis. FRONTIERS IN IMMUNOLOGY, vol. 10, ISSN: 1664-3224, doi: 10.3389/fimmu.2019.02937 - Articolo in rivista 11. Pulvirenti F., Cinetto F., Milito C., Bonanni L., Pesce A. M., Leodori G., Garzi G., Miglionico M., Tabolli S., Quinti I. (2020). Health-Related Quality of Life in Common Variable Immunodeficiency Italian Patients Switched to Remote Assistance During the COVID-19 Pandemic. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. IN PRACTICE, p. 1-6, ISSN: 2213-2198, doi: 10.1016/j.jaip.2020.04.003 - Articolo in rivista 12. Pulvirenti F., Milito C., Cavaliere F. M., Mezzaroma I., Cinetto F., Quinti I. (2020). IGA Antibody Induced by Immunization With Pneumococcal Polysaccharides Is a Prognostic Tool in Common Variable Immune Deficiencies. FRONTIERS IN IMMUNOLOGY, vol. 11, ISSN: 1664-3224, doi: 10.3389/fimmu.2020.01283 - Articolo in rivista 13. Milito, Cinzia, Pulvirenti, Federica, Cinetto, Francesco, Lougaris, Vassilios, Soresina, Annarosa, Pecoraro, Antonio, Vultaggio, Alessandra, Carrabba, Maria, Lassandro, Giuseppe, Plebani, Alessandro. (2019). Double-Blind, Placebo-Controlled Randomized Trial on Low Dose Azithromycin Prophilaxis in Primary Antibody Deficiencies. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN: 0091-6749, doi: 10.1016/j.jaci.2019.01.051 - Articolo in rivista 14. Na, Il-Kang, Buckland, Matthew, Agostini, Carlo, Edgar, John David M., Friman, Vanda, Michallet, Mauricette, Sánchez-Ramón, Silvia, Scheibenbogen, Carmen, Quinti, Isabella (2019). Current clinical practice and challenges in the management of secondary immunodeficiency in hematological malignancies. EUROPEAN JOURNAL OF HAEMATOLOGY, vol. 102, p. 447-456, ISSN: 0902-4441, doi: 10.1111/ejh.13223 - Articolo in rivista 15. Prezzo A., Cavaliere F. M., Bilotta C., Pentimalli T. M., Iacobini M., Cesini L., Foa R., Mauro F. R., Quinti I. (2019). Ibrutinib-based therapy impaired neutrophils microbicidal activity in patients with chronic lymphocytic leukemia during the early phases of treatment. LEUKEMIA RESEARCH, vol. 87, ISSN: 0145-2126, doi: 10.1016/j.leukres.2019.106233 - Articolo in rivista 16. Pulvirenti, Federica, Camilli, Romina, Giufrè, Maria, Milito, Cinzia, Pimentel de Araujo, Fernanda, Mancini, Fabiola, Cardines, Rita, Ciervo, Alessandra, Pantosti, Annalisa, Cerquetti, Marina. (2018). Risk factors for Haemophilus influenzae and pneumococcal respiratory tract colonization in CVID. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN: 0091-6749, doi: 10.1016/j.jaci.2018.08.014 - Articolo in rivista 17. Pulvirenti, Federica, Pecoraro, Antonio, Cinetto, Francesco, Milito, Cinzia, Valente, Michele, Santangeli, Enrico, Crescenzi, Ludovica, Rizzo, Francesca, Tabolli, Stefano, Spadaro, Giuseppe. (2018). Gastric cancer is the leading cause of death in Italian adult patients with common variable immunodeficiency. FRONTIERS IN IMMUNOLOGY, vol. 9, p. 1-12, ISSN: 1664-3224, doi: 10.3389/fimmu.2018.02546 - Articolo in rivista 18. CAVALIERE, Filomena Monica, PREZZO, ALESSANDRO, Bilotta, Caterina, IACOBINI, Metello, QUINTI, Isabella (2017). The lack of BTK does not impair monocytes and polymorphonuclear cells functions in X-linked agammaglobulinemia under treatment with intravenous immunoglobulin replacement. PLOS ONE, vol. 12, ISSN: 1932-6203, doi: 10.1371/journal.pone.0175961 - Articolo in rivista 19. Carss, Keren J., Arno, Gavin, Erwood, Marie, Stephens, Jonathan, Sanchis Juan, Alba, Hull, Sarah, Megy, Karyn, Grozeva, Detelina, Dewhurst, Eleanor, Malka, Samantha. (2017). Comprehensive Rare Variant Analysis via WholeGenome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease. AMERICAN JOURNAL OF HUMAN GENETICS, vol. 100, p. 75-90, ISSN: 0002-9297, doi: 10.1016/j.ajhg.2016.12.003 - Articolo in rivista 20. Quinti, Isabella, Mitrevski, Milica (2017). Modulatory Effects of Antibody Replacement Therapy to Innate and Adaptive Immune Cells. FRONTIERS IN IMMUNOLOGY, vol. 8, ISSN: 1664-3224, doi: 10.3389/fimmu.2017.00697 - Articolo in rivista

External links

• Isabella Quinti - Google Scholar
• Isabella Quinti - Scopus
• Isabella Quinti - Head Primary Immune Deficiencies Unit - Sapienza University of Rome - Department of Molecular Medicine - Research profile