Daniele De Luca

Daniele De Luca is a Full Professor of Pediatrics (Neonatology) and head of the Division of Pediatrics and Neonatal Critical Care at the “A. Beclere” Hospital belonging to APHP-Paris Saclay University, where he has an intense clinical and research activity. He has been the youngest Division Chief (appointed at 35 years old) and one of the youngest Professors of Pediatrics (appointed as associate and full professor at 37 and 42 years old) in Europe. His hospital is the main perinatal center in France including one of the biggest European neonatal intensive care units.

Daniele De Luca

Born	Rome, Italy
Nationality	Italian
Education	Catholic University of the Sacred Heart (Rome, Italy)
	Paris Sorbonne University
Fields	Neonatal and Pediatric Critical Care
Institutions	Assistance Publique-Hopitaux de Paris (Since 2013)
	Paris Saclay University (Since 2015)
Notes
Top Italian Scientist in Clinical Sciences

For his research activity he is a member of INSERM, belonging to Physiopathology and Therapeutic Innovation Unit and has been collaborating as associate researcher with the Institut Pasteur. His research focuses on respiratory critical care from different points of view (namely surfactant catabolism, lung tissue inflammation, lung ultrasound, respiratory support techniques, and ARDS epidemiology). He was the first in clarifying the role of secretory phospholipase A2 in surfactant catabolism and the effect of therapeutic hypothermia on lung biology and function. He introduced lung ultrasound in neonatal critical care and invented the neonatal lung ultrasound score now used worldwide, as well as the ultrasound-guided surfactant administration. Regarding respiratory support he has been actively studying the refinement of non-invasive respiratory support techniques to spare invasive ventilation in preterm babies: his bench studies allowed the clinical application of nasal high frequency oscillatory ventilation, which he then tested on a large scale with a French-Chinese collaboration. Finally, he has been responsible for the movement leading to the recognition of the existence of neonatal ARDS (see below the main publications for each of these research areas). His research has received more than 350K Euros of funding from several bodies.

During his career Prof. De Luca’s also worked on two ancillary topics. One is neonatal jaundice as he performed several studies on skin bilirubin kinetics. He drew the first European nomogram of skin bilirubin to be used for daily management in nursery for which he received the Acta Paediatrica Young Investigator Award. The second is the effect of pandemics on newborn health. His group discovered SARS-CoV-2 mother-to-child transmission, and studied the phenomenon using a multidisciplinary (clinical, virology, pathology) approach; he served as World Health Organization Advisor and was a member of the WHO committee issuing the definition for perinatal and neonatal SARS-CoV-2 infection. His works on neonatal COVID-19 had received worldwide mass-media coverage.

All in all, he is an advocate for a pathophysiological based critical care, using several monitoring and therapeutic techniques even for the smallest babies. Recently he was one of the founder of the French network of neonatal extracorporeal renal replacement therapy and his work was the first in applying this to preterm babies. He is an advocate for a more active and translational research to advance neonatal/pediatric critical care. For this reason, together with the Editor of Lancet Child Health, he launched the Lancet Commission on the Future of Neonatology, with the participation of the EU Commissioner on healthcare.

His secondary interests brought him to be interested in hospital/medical management and in bioethics applied to neonatal and perinatal care, for which he collaborates with the Pontifical Academy of life. He is listed amongst the top Italian scientist in the category of "clinical sciences".